Systems approaches to studying the immune response in tuberculosis.

Curr Opin Immunol 2013 Oct 7;25(5):579-87. Epub 2013 Sep 7.

Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK; Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, St. Mary's Hospital, London W2 1NY, UK.

Tuberculosis (TB) remains a disease of considerable mortality and morbidity. Studies employing microarrays to derive transcriptional profiles of the host response during TB, which combined with data from experimental systems have highlighted a potentially detrimental role for type I interferons during infection, with important implications for vaccine and therapeutic development. In addition, these studies have provided candidate biomarkers which may advance diagnosis and treatment monitoring. These studies thus exemplify the promise of a systems biology approach to study complex infectious disease such as TB.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2013.08.003DOI Listing
October 2013
4 Reads

Publication Analysis

Top Keywords

implications vaccine
4
infection implications
4
interferons infection
4
vaccine therapeutic
4
therapeutic development
4
addition studies
4
development addition
4
type interferons
4
role type
4
combined data
4
response combined
4
host response
4
data experimental
4
experimental systems
4
highlighted detrimental
4
systems highlighted
4
studies provided
4
provided candidate
4
biology approach
4
systems biology
4

Similar Publications