Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis.

Authors:
Matthew J Anderson
Matthew J Anderson
Saint Joseph's University
Philadelphia | United States
Prof. Dominik R Haudenschild, Ph.D.
Prof. Dominik R Haudenschild, Ph.D.
University of California Davis Medical Center
Professor
Arthritis Research
Sacramento, CA | United States
Blaine A Christiansen
Blaine A Christiansen
Washington University in St. Louis

J Orthop Res 2014 Jan 9;32(1):79-88. Epub 2013 Sep 9.

Department of Orthopaedic Surgery, University of California-Davis Medical Center, 4635 2nd Ave, Suite 2000, Sacramento, California, 95817.

Post-traumatic osteoarthritis (PTOA) is a common long-term consequence of joint injuries such as anterior cruciate ligament (ACL) rupture. In this study we used a tibial compression overload mouse model to compare knee injury induced at low speed (1 mm/s), which creates an avulsion fracture, to injury induced at high speed (500 mm/s), which induces midsubstance tear of the ACL. Mice were sacrificed at 0 days, 10 days, 12 weeks, or 16 weeks post-injury, and joints were analyzed with micro-computed tomography, whole joint histology, and biomechanical laxity testing. Knee injury with both injury modes caused considerable trabecular bone loss by 10 days post-injury, with the Low Speed Injury group (avulsion) exhibiting a greater amount of bone loss than the High Speed Injury group (midsubstance tear). Immediately after injury, both injury modes resulted in greater than twofold increases in total AP joint laxity relative to control knees. By 12 and 16 weeks post-injury, total AP laxity was restored to uninjured control values, possibly due to knee stabilization via osteophyte formation. This model presents an opportunity to explore fundamental questions regarding the role of bone turnover in PTOA, and the findings of this study support a biomechanical mechanism of osteophyte formation following injury.

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http://dx.doi.org/10.1002/jor.22480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140447PMC

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January 2014
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References

(Supplied by CrossRef)
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Felson et al.
Epidemiol Rev 1988
Biomechanics of anterior cruciate ligament failure: an analysis of strain-rate sensitivity and mechanisms of failure in primates
Noyes et al.
J Bone Joint Surg Am 1976

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