Search Our Scientific Publications & Authors

Nan Fang Yi Ke Da Xue Xue Bao 2019 Sep;39(9):1083-1088

Department of Pharmacy, Hefei BOE Hospital, Anhui, Hefei 230041, China.

Objective: To study the expressions of the members of HSP110 family in the testis and epididymis of mice at different stages of development and whether they are regulated by hormones.

Methods: The testicular and epididymis tissues of mice at different ages (14, 21, 28, 35, 42, 49, 70, and 90 days after birth, 3 mice at each age) were collected for RT-PCR detection of the expression levels of HSP110 family members. Forty-eight mice were randomized into 3 groups for sham operation, castration, or castration with testosterone injections every other day (starting at 7 days after castration), and at 1, 3, 5, and 7 days after first testosterone injection, the expressions of HSP110 family in the epididymis were detected using RT-PCR. Read More

Andrologia 2018 Jun 12;50(5):e12999. Epub 2018 Mar 12.

Department of Urology, Cleveland Clinic, Cleveland, OH, USA.

Nonobstructive azoospermia (NOA) patients present with high levels of serum FSH. At the protein level, the aetiology and pathways underlying different subtypes of NOA are unclear. The aim was to evaluate quantitatively differences in proteomic profiles of NOA patients presenting with normal serum FSH and normal testicular volume and high serum FSH and small testicular volume. Read More

J Endod 2016 Oct 25;42(10):1467-71. Epub 2016 Aug 25.

Center for Craniofacial Research, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas; Department of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas. Electronic address:

Introduction: Heat shock proteins (HSPs) protect cells under adverse conditions such as infection, inflammation, and disease. The differential expression of HSPs in human periapical granulomas suggests a potential role for these proteins in periapical lesion development, which may contribute to different clinical outcomes. Therefore, we hypothesized that polymorphisms in HSP genes leading to perturbed gene expression and protein function may contribute to an individual's susceptibility to periapical lesion development. Read More

PLoS One 2016 2;11(8):e0160312. Epub 2016 Aug 2.

Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, United States of America.

Heat shock proteins (Hsps) are known to associate with estrogen receptors (ER) and regulate ER-mediated cell proliferation. Historically, the studies in this area have focused on Hsp90. However, some critical aspects of the Hsp-ERα interactions remain unclear. Read More

Int J Med Sci 2015 15;12(3):256-63. Epub 2015 Feb 15.

1. Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China;

Background: Heat shock proteins (HSPs) are overexpressed in human hepatocellular carcinoma (HCC) tissue and correlate with aggressiveness and prognosis of HCC.

Methods: Using the GSE14520 microarray expression profile from Gene Expression Omnibus, we compared HSP gene expression between tumour and non-tumour tissues and correlated this with outcomes in HCC patients.

Results: We analysed 220 hepatitis B virus (HBV)-related HCC patients and 25 HSPs in this study. Read More