Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system.

Authors:
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Front Physiol 2013 12;4:209. Epub 2013 Aug 12.

Department of Translational Medical Sciences, "Federico II" University Naples, Italy ; Department of Advanced Biomedical Sciences, "Federico II" University Naples, Italy ; College of Physicians and Surgeons, New York Presbyterian Hospital, Columbia University in the City of New York Manhattan, New York, NY, USA.

Aging is a complex process characterized by a gradual decline in organ functional reserves, which eventually reduces the ability to maintain homeostasis. An exquisite feature of elderly subjects, which constitute a growing proportion of the world population, is the high prevalence of cardiovascular disorders, which negatively affect both the quality of life and the life expectancy. It is widely acknowledged that physical activity represents one of the foremost interventions capable in reducing the health burden of cardiovascular disease. Interestingly, the benefits of moderate-intensity physical activity have been established both in young and elderly subjects. Herein we provide a systematic and updated appraisal of the literature exploring the pathophysiological mechanisms evoked by physical activity in the elderly, focusing on the functional role of the β adrenergic system.

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Source
http://dx.doi.org/10.3389/fphys.2013.00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740240PMC

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August 2013
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