Angew Chem Int Ed Engl 2013 Sep 12;52(39):10352-5. Epub 2013 Aug 12.
Corporate R&D Division, Firmenich SA route des Jeunes 1, P.O. Box 239, 1211 Genève 8 (Switzerland).
Chem Rev 2022 May 20. Epub 2022 May 20.
InCatT B.V., Science Park 904, 1098 XH Amsterdam, The Netherlands.
Transition metal catalysis is of utmost importance for the development of sustainable processes in academia and industry. The activity and selectivity of metal complexes are typically the result of the interplay between ligand and metal properties. As the ligand can be chemically altered, a large research focus has been on ligand development. Read More
Org Biomol Chem 2022 May 13. Epub 2022 May 13.
Organization for the Strategic Coordination of Research and Intellectual Properties, Meiji University, 1-1-1, Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
Resolvin D3 was synthesized by the Suzuki-Miyaura cross-coupling reaction of C1-C8 borane with C9-C22 iodoolefin as the key reaction. The latter intermediate was obtained by the sequential Wittig reactions of C9-C13 phosphonium salt with C14-C19 aldehyde and then C9-C19 aldehyde with propyltriphenylphosphonium bromide. The stereogenic centers at C4, C11, and C17 were constructed by the ruthenium-catalyzed asymmetric transfer hydrogenation with high stereoselectivity. Read More
Angew Chem Int Ed Engl 2022 May 11. Epub 2022 May 11.
Institut de Recerca Biomedica, Parc Científic de Barcelona, Department of Organic Chemistry, C/ Baldiri Reixac 10, 08028, Barcelona, SPAIN.
Chiral compounds containing nitrogen heteroatoms are fundamental substances for the chemical, pharmaceutical and agrochemical industries. However, the preparation of some of these interesting scaffolds is still underdeveloped. Herein we present the synthesis of a new family of P-stereogenic phosphinooxazoline iridium catalysts from L-threonine methyl ester and its use in the asymmetric hydrogenation of N -Boc-2,3-diarylallyl amines, achieving very high enantioselectivity. Read More
J Chem Phys 2022 05;156(17):179901
Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Department of Electronic Science, Xiamen University, 361005 Xiamen, China.
J Am Chem Soc 2022 May 5;144(19):8734-8740. Epub 2022 May 5.
Department of Organic Chemistry, Stockholm University, Svante Arrhenius väg 16C, SE-10691Stockholm, Sweden.
Asymmetric hydrogenation of prochiral substrates such as ketones and olefins constitutes an important instrument for the construction of stereogenic centers, and a multitude of catalytic systems have been developed for this purpose. However, due to the different nature of the π-system, the hydrogenation of olefins and ketones is normally catalyzed by different metal complexes. Herein, a study on the effect of additives on the Ir-N,P-catalyzed hydrogenation of enones is described. Read More