Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Monocyte count at diagnosis is a prognostic parameter in diffuse large B-cell lymphoma: results from a large multicenter study involving 1191 patients in the pre- and post-rituximab era.

Authors:
Tamar Tadmor Alessia Bari Stefano Sacchi Luigi Marcheselli Eliana Valentina Liardo Irit Avivi Noam Benyamini Dina Attias Samantha Pozzi Maria Christina Cox Luca Baldini Maura Brugiatelli Massimo Federico Aaron Polliack

Haematologica 2014 Jan 9;99(1):125-30. Epub 2013 Aug 9.

In this study we assessed the prognostic significance of absolute monocyte count and selected the best cut-off value at diagnosis in a large cohort of patients with diffuse large B-cell lymphoma. Data were retrieved for therapy-naïve patients with diffuse large B-cell lymphoma followed in Israel and Italy during 1993-2010. A final cohort of 1017 patients was analyzed with a median follow up of 48 months and a 5-year overall survival rate of 68%. The best absolute monocyte count cut-off level was 630/mm(3) and the 5-year overall survival for patients with counts below this cut-off was 71%, whereas it was 59% for those with a count >630 mm(3) (P=0.0002). Of the 1017 patients, 521 (51%) were treated with chemo-immunotherapy, and in this cohort, using multivariate analysis, elevated monocyte count retained a negative prognostic value even when adjusted for International Prognostic Index (HR1.54, P=0.009). This large study shows that a simple parameter such as absolute monocyte count (>630/mm(3)) can easily be used routinely in the evaluation of newly diagnosed diffuse large B-cell lymphoma to identify high-risk patients with a worse survival in the rituximab era.

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2013.088161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007925PMC
January 2014

Publication Analysis

Top Keywords

monocyte count
20
b-cell lymphoma
16
diffuse large
16
large b-cell
16
absolute monocyte
12
1017 patients
8
patients diffuse
8
5-year survival
8
patients
7
large
7
count
5
monocyte
5
best absolute
4
count >630/mm3
4
68% best
4
survival patients
4
level 630/mm3
4
cut-off level
4
>630/mm3 easily
4
count cut-off
4

Keyword Occurance

Similar Publications

Association of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with in-hospital mortality in the early phase of severe trauma.

Authors:
Dong Hun Lee Byung Kook Lee Sung Min Lee Yong Soo Cho Seong Woo Yun

Ulus Travma Acil Cerrahi Derg 2021 May;27(3):290-295

Department of Emergency Medical Technology, Namseoul University, Chungnam-South Korea.

Background: This study aimed to examine the relationship between the immediate and early complete blood count-based scores and prognosis in trauma patients.

Methods: This retrospective observational study included adult patients admitted for severe trauma between January 2014 and December 2018. Multivariate logistic regression analysis was conducted to assess the association between the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), and in-hospital mortality. Read More

View Article and Full-Text PDF
May 2021
Similar Publications

Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study.

Authors:
Mazen M Ghaith Mohammad A Albanghali Abdullah F Aldairi Mohammad S Iqbal Riyad A Almaimani Khalid AlQuthami Mansour H Alqasmi Wail Almaimani Mahmoud Zaki El-Readi Ahmad Alghamdi Hussain A Almasmoum

Can J Infect Dis Med Microbiol 2021 10;2021:6656092. Epub 2021 Apr 10.

Laboratory Medicine Department, Umm Al-Qura University, Al Abdeyah, Makkah 7607, Saudi Arabia.

Background: Timely detection of the progression of the highly contagious coronavirus disease (COVID-19) is of utmost importance for management and intervention for patients in intensive care (ICU).

Aim: This study aims to better understand this new infection and report the changes in the various laboratory tests identified in critically ill patients and associated with poor prognosis among COVID-19 patients admitted to the ICU.

Methods: This was a retrospective study that included 160 confirmed SARS-CoV-2-positive patients. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

A lower admission level of interleukin-6 is associated with first-pass effect in ischemic stroke patients.

Authors:
Laura Mechtouff Thomas Bochaton Alexandre Paccalet Claire Crola Da Silva Marielle Buisson Camille Amaz Laurent Derex Elodie Ong Yves Berthezene Nathalie Dufay Michel Ovize Nathan Mewton Tae-Hee Cho Norbert Nighoghossian Omer F Eker

J Neurointerv Surg 2021 Apr 21. Epub 2021 Apr 21.

Neuroradiology Department, Hospices Civils de Lyon, Lyon, France.

Background: First-pass effect (FPE) defined as a complete or near-complete reperfusion achieved after a single thrombectomy pass is predictive of favorable outcome in acute ischemic stroke (AIS) patients. We aimed to assess whether admission levels of inflammatory markers are associated with FPE.

Methods: HIBISCUS-STROKE (CoHort of Patients to Identify Biological and Imaging markerS of CardiovascUlar Outcomes in Stroke) includes AIS patients with large vessel occlusion treated with mechanical thrombectomy following brain MRI. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Immunological effect of irreversible electroporation on hepatocellular carcinoma.

Authors:
Xiaoxia Guo Fang Du Qin Liu Yan Guo Qingbing Wang Wei Huang Zhongmin Wang Xiaoyi Ding Zhiyuan Wu

BMC Cancer 2021 Apr 21;21(1):443. Epub 2021 Apr 21.

Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE).

Methods: We evaluated the systemic immune response in patients with hepatocellular carcinoma (HCC) after IRE treatment. Furthermore, we analyzed the tumor infiltrating T lymphocytes and the level of serum cytokines in IRE and control groups of tumor-bearing mice. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Hematology and biochemistry of buffalo (Bubalus bubalis): influence of sex and age on reference values.

Authors:
Thais Bastos Rocha Ruan da Cruz Paulino Diego Moraes Soares Wendel Adelino Policarpo Ednaldo da Silva Filho Maria Vivina Barros Monteiro Michelly Fernandes de Macedo Helder de Moraes Pereira

Trop Anim Health Prod 2021 Apr 20;53(2):273. Epub 2021 Apr 20.

Post Graduate Program in Animal Science, Universidade Estadual do Maranhão (UEMA), Cidade Universitária Paulo VI, s/n°, Bairro Tirirical, São Luís, Maranhão, 65055970, Brazil.

This research aimed to obtain a hematological and biochemical profile of buffalos (Bubalus bubalis) bred in a region of the Brazilian Legal Amazon. A total of 73 animals of mixed races, divided into three groups, were studied: group 1 (G1) comprised animals up to 11 months old; in group 2 (G2), subjects were 12 to 23 months old; and, in group 3 (G3), they were 24 months old and older. We performed the hematological analysis manually, and, for the biochemistry, we used biochemical analyzers. Read More

View Article and Full-Text PDF
April 2021
Similar Publications
© 2021 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap