Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Authors:

Nat Genet 2013 Sep 11;45(9):984-94. Epub 2013 Aug 11.

The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia.

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800159PMC
September 2013
157 Reads

Article Mentions


Provided by Crossref Event Data
f1000
F1000: F1000
September 18, 2013, 8:00 pm EST
reddit-links
Reddit-links: Reddit-links
December 1, 2015, 2:16 pm EST
crossref
Crossref: Crossref
February 25, 2018, 7:00 pm EST
wikipedia
Wikipedia: Enfermidade mental
October 16, 2017, 7:38 am EST
wikipedia
Wikipedia: Psychiatric epidemiology
September 8, 2017, 12:00 pm EST
wikipedia
Wikipedia: Enfermedad mental
June 14, 2017, 5:25 am EST
wikipedia
Wikipedia: History of psychiatry
June 11, 2017, 4:24 pm EST
twitter
Twitter: Angelaolsson1
May 12, 2017, 5:13 pm EST
twitter
Twitter: Lindbergpolemik
May 12, 2017, 1:23 pm EST
twitter
Twitter: AmirSariaslan
May 12, 2017, 12:18 pm EST
twitter
Twitter: Tgegwang
February 24, 2017, 5:02 am EST

Publication Analysis

Top Keywords

psychiatric disorders
16
major depressive
16
depressive disorder
16
bipolar disorder
12
disorders
10
schizophrenia bipolar
8
genetic etiology
8
genetic variation
8
disorder
8
disorder major
8
shared genetic
8
genetic
6
psychiatric
5
estimation genetic
4
methods estimation
4
variation covariation
4
disorders snps
4
bivariate methods
4
snps explained
4
disorders negative
4

References

(Supplied by CrossRef)
Article in Am. J. Med. Genet. C. Semin. Med. Genet.
JW Smoller et al.
Am. J. Med. Genet. C. Semin. Med. Genet. 2003
Article in J. Child Psychol. Psychiatry
A Ronald et al.
J. Child Psychol. Psychiatry 2008
Article in Eur. Child Adolesc. Psychiatry
NN Rommelse et al.
Eur. Child Adolesc. Psychiatry 2010
Article in Am. J. Psychiatry
P Lichtenstein et al.
Am. J. Psychiatry 2010
Article in J. Am. Acad. Child Adolesc. Psychiatry
J Rapoport et al.
J. Am. Acad. Child Adolesc. Psychiatry 2009
Article in Brain Res.
BH King et al.
Brain Res. 2011
Article in Arch. Gen. Psychiatry
PF Sullivan et al.
Arch. Gen. Psychiatry 2012
Article in Proc. Natl. Acad. Sci. USA
B Crespi et al.
Proc. Natl. Acad. Sci. USA 2010
Article in Psychol. Med.
PB Mortensen et al.
Psychol. Med. 2010
Article in Am. J. Psychiatry
SV Faraone et al.
Am. J. Psychiatry 2012
Article in J. Am. Acad. Child Adolesc. Psychiatry
J Cole et al.
J. Am. Acad. Child Adolesc. Psychiatry 2009

Similar Publications