Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny.

Science 2013 Aug;341(6145):565-9

Dipartimento di Scienze della Natura e del Territorio, Università di Sassari, Sassari, Italy.

Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates.

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http://dx.doi.org/10.1126/science.1237947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500864PMC
August 2013
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References

(Supplied by CrossRef)

Skaletsky et al.
Nature; Physical Science (London) 2003

Underhill et al.
Nature genetics 2000

Semino et al.
Science 2000

Genome Research 2013

Scally et al.
Nature reviews. Genetics 2012

Gibbons et al.
Science 2012

Keller et al.
2012

Francalacci et al.
American Journal of Physical Anthropology 2003

Rootsi et al.
American journal of human genetics 2004

Olivieri et al.
Science 2006

American journal of human genetics 2013

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