To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Maddalena Illario
Maddalena Illario
University of Naples Federico II
Napoli | Italy
Rosa Finelli
Rosa Finelli
University of Salerno
Fisciano | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Transl Med UniSa 2012 Sep 11;4:73-85. Epub 2012 Oct 11.

Department of Clinical Medicine, Cardiovascular and Immunological Science, Federico II University of Naples, Italy.

Nuclear factor κB (NFκB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFκB is constitutively expressed in tumours where it induces the expression of genes which promote cell proliferation, apoptotic events, angiogenesis, invasion and metastasis. Furthermore, many cancer cells show aberrant or constitutive NFκB activation that mediates resistance to chemo- and radio-therapy. Therefore, the inhibition of NFκB activity appears a potential therapeutic strategy for cancer treatment. In this review, we focus on the role of NFκB in carcinogenesis and summarize actual inhibitors of NFκB that could be potential therapeutic target in cancer therapy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728801PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
September 2012
10 Reads
9 Citations

Publication Analysis

Top Keywords

potential therapeutic
8
nfκb
7
aberrant constitutive
4
cells aberrant
4
cancer cells
4
constitutive nfκb
4
metastasis cancer
4
mediates resistance
4
activation mediates
4
nfκb activation
4
resistance chemo-
4
angiogenesis invasion
4
genes promote
4
expression genes
4
induces expression
4
tumours induces
4
promote cell
4
cell proliferation
4
chemo- radio-therapy
4
events angiogenesis
4

Similar Publications