Protocol of an observational study to evaluate diabetic nephropathy through detection of microalbuminuria in Indian patients.

Authors:
Manisha Sahay
Manisha Sahay
Osmania General Hospital
India
Sanjay Kalra
Sanjay Kalra
Bharti Hospital
Pune | India
Vijay Vishwanathan
Vijay Vishwanathan
Diabetes Research Centre and MV Hospital for Diabetes
Abdul Hamid Zargar
Abdul Hamid Zargar
Sher-i-Kashmir Institute of Medical Sciences
India
Pradeep G Talwalkar
Pradeep G Talwalkar
S.L. Raheja Hospital
Subhash Kuamr Wangnoo
Subhash Kuamr Wangnoo
St. Johns Medical College Hospital
India
Debasish Maji
Debasish Maji
Vivekananda Institute of Medical Sciences
Kolkata | India

Indian J Endocrinol Metab 2013 May;17(3):496-504

Department of Nephrology, St. Johns Medical College Hospital, Bangalore, India.

Aim: To assess the prevalence of persistent microalbuminuria (MAU), its clinical correlates by dip stick method, its predictive value for potential kidney disease and the utility of this test as objective cue for health care seeking behavior in adult Indian patients with type 2 diabetes mellitus.

Materials And Methods: Approximately 400,000 patients shall be enrolled in this multicentric, cross sectional study. Patients meeting eligibility criteria shall be screened for MAU through urine dipstick test using random daytime single spot urine specimen. Result shall be expressed either positive or negative based on the presence or absence of albumin in the urine and will be correlated with the corresponding random blood glucose. Height, weight, waist circumference and blood pressure shall be assessed. There will be three visits with a minimum interval of 28 days between two visits, to be completed within 180 days, and at least two of three urine tests measured in this period must show elevated albumin levels to diagnose MAU.

Conclusion: Detection of MAU through the dipstick method is postulated to be a rapid, reliable test for early detection of diabetic nephropathy, which, in turn will help the physician to plan treatment strategy. Further, it will help to identify the disease burden on the individual and society, and may serve as an objective cue for improved health care seeking behavior, as well as a catalyst for health policy change.

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Source
http://dx.doi.org/10.4103/2230-8210.111655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712383PMC

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May 2013
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