Reduction in choroidal thickness of macular area in polypoidal choroidal vasculopathy patients after intravitreal ranibizumab therapy.

Graefes Arch Clin Exp Ophthalmol 2013 Oct 18;251(10):2415-20. Epub 2013 Jul 18.

Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama-city, Kanagawa, Japan, 236-0004,

Background: To evaluate changes in retinal and choroidal thickness changes after three intravitreal ranibizumab (IVR) injections for polypoidal choroidal vasculopathy (PCV) using enhanced depth-imaging-optical coherence tomography (EDI-OCT).

Methods: In this retrospective, observational case series, EDI-OCT was used to measure changes in choroidal thickness at nine points in a lattice shape in the macula before and after introductory-stage IVR.

Results: Choroidal thickness was decreased at all nine points in the lattice shape, but was significantly decreased only at the fovea.

Conclusion: The subfoveal choroidal thickness may be reduced by introductory-stage IVR in patients with PCV. In particular, choroidal thickness at the fovea was reduced during the early stage of treatment.

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Source
http://dx.doi.org/10.1007/s00417-013-2419-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777170PMC
October 2013
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