Interleukin-7: Fuel for the autoimmune attack.

Authors:

J Autoimmun 2013 Sep 4;45:40-8. Epub 2013 Jul 4.

Department of Medicine, Arthritis Center/Rheumatology Section, Boston University School of Medicine, 72 East Concord Street, E519, Boston, MA 02118, USA. Electronic address:

Interleukin-7 (IL-7) is a critical survival factor for lymphocytes and recent studies suggest targeting the IL-7/IL-7Rα pathway holds promise for the treatment of autoimmune diseases. Several lines of evidence, genetic as well as functional, indicate an important role for this cytokine in autoimmune inflammation: polymorphisms in the IL-7Rα have been associated with increased risk for autoimmune disease and blocking IL-7/IL-7Rα with antibodies showed therapeutic efficacy in several autoimmune mouse models. Insights are starting to emerge about the mechanisms underlying IL-7's role in autoimmunity and tolerance, revealing surprising novel functions beyond its traditional activity as a T cell survival factor. In the first part of this review, the functions of IL-7 in the immune system are concisely described, providing a basis for understanding their potential role in promoting autoimmune responses. In the second part, current knowledge about the role of IL-7 in various autoimmune conditions is reviewed.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2013.06.007DOI Listing
September 2013
4 Reads

Publication Analysis

Top Keywords

survival factor
8
autoimmune
7
mechanisms underlying
4
underlying il-7's
4
emerge mechanisms
4
insights starting
4
il-7's role
4
starting emerge
4
role autoimmunity
4
surprising novel
4
novel functions
4
revealing surprising
4
tolerance revealing
4
autoimmunity tolerance
4
models insights
4
mouse models
4
risk autoimmune
4
autoimmune disease
4
increased risk
4
associated increased
4

Similar Publications