Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response.

Authors:
Strahinja Stojadinovic, Ph.D.
Strahinja Stojadinovic, Ph.D.
UT Southwestern Medical Center
Associate Professor
Medical Physics
Dallas, TX | United States

Magn Reson Med 2014 May 27;71(5):1863-73. Epub 2013 Jun 27.

Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Purpose: To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response.

Methods: BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent (19) F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments.

Results: Oxygen (100%O2 ) and carbogen (95%O2 /5%CO2 ) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative (19) F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay.

Conclusion: These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2 . Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.

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Source
http://dx.doi.org/10.1002/mrm.24846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883977PMC
May 2014
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References

(Supplied by CrossRef)
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
Höckel et al.
Cancer Res 1996

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