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Int J Immunopathol Pharmacol 2023 ;37:3946320231202349

Department of Immunology, College of Medicine, Konkuk University, Chungju, Republic of Korea.

Our objective was to assess the effects and mechanisms of nifuratel on IgE-mediated mast cell (MC) degranulation and anaphylaxis in both in vitro and in vivo settings. The anti-allergic activity of nifuratel was evaluated in mast cell cultures and the passive cutaneous anaphylaxis (PCA) model. The effects of nifuratel on signaling pathways stimulated by antigen in mast cells were measured by immunoblotting, immunoprecipitation, in vitro protein tyrosine kinase assay, and other molecular biological methods. Read More

Int Immunopharmacol 2023 Sep 8;124(Pt A):110874. Epub 2023 Sep 8.

Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. Electronic address:

Pseudo-allergic reaction is an allergic reaction mediated by nonimmunoglobulin E (IgE), which does not require prior contact with antigen sensitization and directly leads to mast cell degranulation. Daphnetin (DAP) is known for its anti-inflammatory effects, but there are few studies on the effect of DAP on pseudo-allergy and its mechanism. To investigate the effect of DAP on pseudo-allergy and its mechanism, we inflicted pseudo-allergy on RBL-2H3 cells using C48/80 in vitro. Read More

Biophysica 2022 Dec 7;2(4):428-439. Epub 2022 Nov 7.

BioFrontiers Center, University of Colorado Colorado Springs, Colorado Springs, CO 80918, USA.

The RBL-2H3 mast cell immunological synapse dynamics is often simulated with reaction-diffusion and Fokker-Planck equations. The equations focus on how the cell synapse captures receptors following an immune response, where the receptor capture at the immunological site appears to be a delayed process. This article investigates the physical nature and mathematics behind such time-dependent delays. Read More

Fitoterapia 2023 Aug 3:105633. Epub 2023 Aug 3.

College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China). Electronic address:

Six previously undescribed sesquiterpenoids, chrysanthterpenoids H-M (1-6), were isolated from the stem and leaves of Chrysanthemum morifolium Ramat. Structure elucidation of isolated compounds was unambiguously determined based on extensive 1D and 2D NMR spectroscopic analyses. Furthermore, computational prediction of ECD was used to propose the absolute configurations of the compounds. Read More

J Ethnopharmacol 2024 Jan 23;318(Pt A):116942. Epub 2023 Jul 23.

College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China. Electronic address:

Ethnopharmacological Relevance: The incidence of allergic disease is constantly increasing, but its pathogenesis is not fully understood. Saposhnikovia divaricata (SD), called 'Fangfeng' in China, not only can be used for antipyretic, analgesic and anti-inflammatory as a traditional Chinese medicine, but also as an active ingredient in about 8% prescriptions. However, its effects on type I allergy and pseudoallergy have not been clarified. Read More