Parsimonious inference of hybridization in the presence of incomplete lineage sorting.

Syst Biol 2013 Sep 4;62(5):738-51. Epub 2013 Jun 4.

Department of Computer Science, Rice University, 6100 Main Street, Houston, TX 77005, USA.

Hybridization plays an important evolutionary role in several groups of organisms. A phylogenetic approach to detect hybridization entails sequencing multiple loci across the genomes of a group of species of interest, reconstructing their gene trees, and taking their differences as indicators of hybridization. However, methods that follow this approach mostly ignore population effects, such as incomplete lineage sorting (ILS). Given that hybridization occurs between closely related organisms, ILS may very well be at play and, hence, must be accounted for in the analysis framework. To address this issue, we present a parsimony criterion for reconciling gene trees within the branches of a phylogenetic network, and a local search heuristic for inferring phylogenetic networks from collections of gene-tree topologies under this criterion. This framework enables phylogenetic analyses while accounting for both hybridization and ILS. Further, we propose two techniques for incorporating information about uncertainty in gene-tree estimates. Our simulation studies demonstrate the good performance of our framework in terms of identifying the location of hybridization events, as well as estimating the proportions of genes that underwent hybridization. Also, our framework shows good performance in terms of efficiency on handling large data sets in our experiments. Further, in analysing a yeast data set, we demonstrate issues that arise when analysing real data sets. Although a probabilistic approach was recently introduced for this problem, and although parsimonious reconciliations have accuracy issues under certain settings, our parsimony framework provides a much more computationally efficient technique for this type of analysis. Our framework now allows for genome-wide scans for hybridization, while also accounting for ILS.

Download full-text PDF

Source
http://dx.doi.org/10.1093/sysbio/syt037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739885PMC
September 2013
9 Reads

Publication Analysis

Top Keywords

hybridization
9
incomplete lineage
8
analysis framework
8
gene trees
8
lineage sorting
8
good performance
8
data sets
8
framework
6
estimates simulation
4
ils propose
4
simulation studies
4
gene-tree estimates
4
propose techniques
4
techniques incorporating
4
uncertainty gene-tree
4
incorporating uncertainty
4
framework terms
4
location hybridization
4
hybridization events
4
events well
4

Similar Publications