Activation of signaling receptors: do ligands bind to receptor monomer, dimer, or both?

Authors:
Xiaodong Pang
Xiaodong Pang
Florida State University
United States
Huan-Xiang Zhou
Huan-Xiang Zhou
Florida State University
United States

BMC Biophys 2013 Jun 3;6. Epub 2013 Jun 3.

Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

A recent study by Dietz et al. using single-molecule fluorescence microscopy techniques demonstrates that, in the absence of the ligand InlB, the MET receptor exists as both a monomer and a dimer on the cell membrane, and addition of the ligand leads to increased MET dimerization. Under the crowded conditions of the cell membrane, dimer formation may be a common phenomenon for cell surface receptors. Ligand binding to both monomeric and dimeric receptors may provide parallel routes to receptor activation.

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Source
http://dx.doi.org/10.1186/2046-1682-6-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674895PMC
June 2013
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