Family cluster of Middle East respiratory syndrome coronavirus infections.

N Engl J Med 2013 Jun 29;368(26):2487-94. Epub 2013 May 29.

Global Center for Mass Gatherings Medicine, Ministry of Health, and Al-Faisal University, Riyadh, Saudi Arabia.

A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients.

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1303729DOI Listing
June 2013

Publication Analysis

Top Keywords

mers-cov infection
12
respiratory syndrome
8
syndrome coronavirus
8
ill mers-cov
8
middle east
8
east respiratory
8
mers-cov
6
suspected discovered
4
reservoir suspected
4
family case
4
including clinical
4
case cluster
4
members hospitals
4
cluster mers-cov
4
infection including
4
family members
4
discovered global
4
coronavirus deaths
4
members living
4
novel coronavirus
4

Similar Publications