Search our Database of Scientific Publications and Authors

I’m looking for a
    Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation.
    FEBS Lett 2013 Jun 11;587(13):1988-96. Epub 2013 May 11.
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
    Autophagy is a highly conserved intracytoplasmic degradation pathway for proteins, oligomers, organelles and pathogens. It initiates with the formation of a cup-shaped double membrane structure called the phagophore. The membrane origin for autophagosomes has been a key question for the field. ATG9 and ATG16L1, or their yeast orthologues, are key proteins that regulate autophagosome biogenesis, and may be associated with distinct membrane sources. Here we review the biology of autophagy with a focus on ATG16L1 and ATG9, and we summarise the current knowledge of their trafficking in relation to autophagic stimuli and autophagosome formation.

    Similar Publications

    ATG16L1 meets ATG9 in recycling endosomes: additional roles for the plasma membrane and endocytosis in autophagosome biogenesis.
    Autophagy 2014 Jan 19;10(1):182-4. Epub 2013 Nov 19.
    Department of Medical Genetics; Cambridge Institute for Medical Research; University of Cambridge; Cambridge UK.
    Autophagosomes are formed by double-membraned structures, which engulf portions of cytoplasm. Autophagosomes ultimately fuse with lysosomes, where their contents are degraded. The origin of the autophagosome membrane may involve different sources, such as mitochondria, Golgi, endoplasmic reticulum, plasma membrane, and recycling endosomes. Read More
    Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
    Mol Biol Cell 2012 May 28;23(10):1860-73. Epub 2012 Mar 28.
    London Research Institute, Cancer Research UK, London, United Kingdom.
    Autophagy is a catabolic process essential for cell homeostasis, at the core of which is the formation of double-membrane organelles called autophagosomes. Atg9 is the only known transmembrane protein required for autophagy and is proposed to deliver membrane to the preautophagosome structures and autophagosomes. We show here that mammalian Atg9 (mAtg9) is required for the formation of DFCP1-positive autophagosome precursors called phagophores. Read More
    Methods to analyze SNARE-dependent vesicular fusion events that regulate autophagosome biogenesis.
    Methods 2015 Mar 13;75:19-24. Epub 2014 Nov 13.
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:
    Autophagy is an important catabolic pathway that preserves cellular homeostasis. The formation of autophagosomes is a complex process requiring the reorganization of membranes from different compartments. Here we describe methods to analyze SNARE-dependent vesicular fusion events involving the homotypic and heterotypic fusion of autophagosome precursor structures. Read More
    Atg9 trafficking in autophagy-related pathways.
    Autophagy 2007 May-Jun;3(3):271-4. Epub 2007 May 29.
    Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.
    The origin of the autophagosomal membrane and the lipid delivery mechanism during autophagy remain unsolved mysteries. Some important hints to these questions come from Atg9, which is the only integral membrane protein required for autophagosome formation and considered a membrane carrier in autophagy-related pathways. In S. Read More