rs2072135, a low-penetrance variant for chronic lymphocytic leukaemia?

Br J Haematol 2013 Jul 14;162(2):221-8. Epub 2013 May 14.

Division of Genetics and Epidemiology, Molecular and Population Genetics, Institute of Cancer Research, Sutton, UK.

Recent multi-stage genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that are robustly associated with chronic lymphocytic leukaemia (CLL) risk. Given that most of these SNPs map to non-coding regions of the genome, it suggests that the functional basis of many GWAS signals will be through differential gene expression. By referencing publically accessible expression quantitative trait loci (eQTL) data on lymphoblastoid cells lines (LCLs) we have globally demonstrated an association between GWAS P-values and eQTLs, consistent with much of the variation in CLL risk being defined by variants impacting on gene expression. To explore using eQTL data to select GWAS SNPs for replication, we genotyped rs2072135 (GWAS P-value = 0·0024, eQTL P-value = 1·510(-19)) in five independent case-control series totalling 1968 cases and 3538 controls. While not attaining statistical significance (combined P-value = 1 × 10(-4)), rs2072135 defines a promising risk locus for CLL. Incorporating eQTL information offers an attractive strategy for selecting SNPs from GWAS for validation.

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http://dx.doi.org/10.1111/bjh.12366DOI Listing
July 2013
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References

(Supplied by CrossRef)
Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk
Crowther-Swanepoel et al.
British Journal of Haematology 2011
Quantifying heterogeneity in a meta-analysis
Higgins et al.
Statistics in Medicine 2002

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