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J Agric Food Chem 2022 Aug 9. Epub 2022 Aug 9.

School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa.

New insecticidal genes and approaches for pest control are a hot research area. In the present study, we explored a novel strategy for the generation of insecticidal proteins. The midgut cadherin of () was used as a target to screen materials that have insecticidal activity. Read More

Front Immunol 2022 22;13:926175. Epub 2022 Jul 22.

Department of Rheumatology, Kawasaki Medical School, Kurashiki, Japan.

Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory periodic fever syndrome associated with heterozygous mutations in , which encodes TNF receptor type I (TNFR1). Although possible proinflammatory mechanisms have been proposed, most previous studies were performed using overexpression models, which could lead to undesirable inflammatory responses due to artificial overexpression. It is crucial to reproduce heterozygous mutations at physiological expression levels; however, such studies remain limited. Read More

Anal Chim Acta 2022 Aug 30;1221:340138. Epub 2022 Jun 30.

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

The coexistent pollution of multiple mycotoxins displays a synergistic toxicity effect that significantly threatens human health. Therefore, it is essential to establish a rapid detection method for multi-mycotoxins in food. In this study, red, green, and blue latex microspheres (LMs) were applied as the aflatoxin B (AFB), T-2 toxins (T-2), and zearalenone (ZEN) antibodies labeled tracer, respectively. Read More

Anal Chim Acta 2022 Aug 20;1221:339941. Epub 2022 May 20.

Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour La Santé (DMTS), SIMoS/ Laboratoire Toxines, Récepteurs et Canaux Ioniques, 91191 Gisf-sur-Yvette, France; CNRS, ERL9004, 91191 Gisf-sur-Yvette, France. Electronic address:

The emergent cyclic imine toxins produced by marine dinoflagellates are potent antagonists of nicotinic acetylcholine receptors. Shellfish accumulate cyclic imine toxins following filter-feeding on toxic dinoflagellates vectoring them to humans. Herein is presented a lateral flow test for the detection of cyclic imine toxins based on three new concepts for test strips: i) the immobilization of lipoprotein vesicles in the test-line, ii) the high affinity of neurotoxins for their receptor targets and iii) the use of high porosity glass fiber filter membranes as support for the fabrication of the lateral flow test NeuroTorp (WO2017108115). Read More

PLoS Negl Trop Dis 2022 Aug 5;16(8):e0010207. Epub 2022 Aug 5.

Enteric Diseases and Vaccines Research Unit, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.

Background: Enterotoxigenic Escherichia coli (ETEC) is one of the top aetiologic agents of diarrhea in children under the age of 5 in low-middle income countries (LMICs). The lack of point of care diagnostic tools for routine ETEC diagnosis results in limited data regarding the actual burden and epidemiology in the endemic areas. We evaluated performance of the novel Rapid LAMP based Diagnostic Test (RLDT) for detection of ETEC in stool as a point of care diagnostic assay in a resource-limited setting. Read More