Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa.

J Otolaryngol Head Neck Surg 2013 Apr 15;42:29. Epub 2013 Apr 15.

Department of Otolaryngology, Head and Neck Surgery of Federal University of São Paulo, São Paulo, Brazil.

Objective: To evaluate TGF-β1 expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).

Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-β1 visualization. Then, the percentage of TGF-β1 expression in stroma and epithelium was objectively quantified using UT Morph software.

Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).

Conclusion: The lower percentage of TGF-β1 expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.

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Source
http://dx.doi.org/10.1186/1916-0216-42-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651223PMC
April 2013
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