FGF21 mediates the lipid metabolism response to amino acid starvation.

J Lipid Res 2013 Jul 9;54(7):1786-97. Epub 2013 May 9.

Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain.

Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.

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Source
http://dx.doi.org/10.1194/jlr.M033415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679382PMC
July 2013
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