Plasmon based biosensor for distinguishing different peptides mutation states.

Sci Rep 2013 ;3:1792

Nanostructures, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.

Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

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http://dx.doi.org/10.1038/srep01792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647166PMC
February 2014
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