MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a.

J Cell Physiol 2013 Oct;228(10):2015-23

Department of Clinical and Molecular Medicine Sapienza University, Sant'Andrea Hospital, Rome, Italy.

Cell cycle progression is controlled by numerous mechanisms ensuring correct cell division. The transition from one cell cycle phase to another occurs in an orderly fashion and is regulated by different cellular proteins. Therefore an alteration of the regulatory mechanisms of the cell cycle results in uncontrolled cell proliferation, which is a distinctive feature of human cancers. Recent evidences suggest that microRNAs (miRs) may also control the levels of multiple cell cycle regulators and therefore control cell proliferation. In fact miRs are a class of small non-coding RNAs, which modulate gene expression. They are involved in numerous physiological cellular processes and most importantly accumulating evidence indicates that many miRs are aberrantly expressed in human cancers. In this report we describe that miR-24 directly targets p27(Kip1) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin-dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis.

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.24368DOI Listing
October 2013

Publication Analysis

Top Keywords

cell cycle
16
cell proliferation
12
cell
9
p27kip1 p16ink4a
8
human cancers
8
gene expression
4
expression involved
4
modulate gene
4
non-coding rnas
4
involved numerous
4
rnas modulate
4
physiological cellular
4
accumulating evidence
4
evidence indicates
4
importantly accumulating
4
processes importantly
4
small non-coding
4
cellular processes
4
numerous physiological
4
mirs class
4

Similar Publications