The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals.

J Clin Exp Neuropsychol 2013 3;35(4):421-34. Epub 2013 Apr 3.

Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA.

This study developed and then cross-validated a novel weighting algorithm based on multiple comorbid risk factors (stimulant use, vascular disease, hepatitis C, HIV disease severity, cognitive reserve) to predict cognitive functioning among 366 HIV+ adults. The resultant "risk severity score" was used to differentially weight, as a function of age, the impact and magnitude of multiple risk factors on cognition. Among older adults (≥50 years) the risk severity index was differentially predictive of learning/memory and verbal fluency, whereas among younger adults it was linked to working memory and executive function. Cognitive reserve was found to be the most robust predictor of neurocognition.

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Source
http://www.tandfonline.com/doi/abs/10.1080/13803395.2013.783
Publisher Site
http://dx.doi.org/10.1080/13803395.2013.783000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641576PMC
January 2014

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