Circulating tumor cells in high-risk nonmetastatic colorectal cancer.

Tumour Biol 2013 Oct 29;34(5):2507-9. Epub 2013 Mar 29.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 000161, Rome, Italy,

The identification of patients at higher risk of recurrence after primary colorectal cancer resection is currently one of the challenges facing medical oncologists. Circulating tumor cell (CTC) may represent a surrogate marker of an early spread of disease in patients without overt metastases. Thirty-seven high-risk stages II-III colorectal cancer patients were evaluated for the presence of CTC. Enumeration of CTCs in 7.5 ml of blood was carried out with the FDA-cleared CellSearch system. CTC count was performed after primary tumor resection and before the start of adjuvant therapy. CTC was detected in 22 % of patients with a significant correlation with regional lymph nodes involvement and stage of disease. No significant correlation was found among the presence of CTC and other clinicopathological parameters. These data suggest that CTCs detection might help in the selection of high-risk stage II colorectal cancer patient candidates for adjuvant chemotherapy.

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http://dx.doi.org/10.1007/s13277-013-0752-9DOI Listing
October 2013
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References

(Supplied by CrossRef)

SJ Cohen et al.
Ann Oncol 2009

J Sastre et al.
Ann Oncol 2008

LM Maestro et al.
Anticancer Res 2009

M Thorsteinsson et al.
Anticancer Res 2011

A Lucci et al.
Lancet Oncol 2012

M Thorsteinsson et al.
Eur J Surg Oncol 2011

P Gazzaniga et al.
Ann Oncol 2012

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