Enhanced avoidance habits in obsessive-compulsive disorder.

Authors:
Claire M Gillan
Claire M Gillan
University of Cambridge
United Kingdom
Sharon Morein-Zamir
Sharon Morein-Zamir
University of Cambridge
United Kingdom
Gonzalo P Urcelay
Gonzalo P Urcelay
University of Cambridge
United Kingdom
Akeem Sule
Akeem Sule
University of Cambridge
United Kingdom
Valerie Voon
Valerie Voon
University of Cambridge
United Kingdom
Annemieke M Apergis-Schoute
Annemieke M Apergis-Schoute
University of Cambridge
United Kingdom
Naomi A Fineberg
Naomi A Fineberg
Queen Elizabeth II Hospital
United Kingdom
Barbara J Sahakian
Barbara J Sahakian
University of Cambridge
United Kingdom

Biol Psychiatry 2014 Apr 16;75(8):631-8. Epub 2013 Mar 16.

Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge; Department of Psychology, University of Cambridge, Cambridge.

Background: Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensitive to goal value. We tested if OCD patients have a bias toward habits using a novel shock avoidance task. To explore how habits, as a putative model of compulsivity, might relate to obsessions and anxiety, we recorded measures of contingency knowledge, explicit fear, and physiological arousal.

Methods: Twenty-five OCD patients and 25 control subjects completed a shock avoidance task designed to induce habits through overtraining, which were identified using goal-devaluation. The relationship between habitual behavior, erroneous cognitions, and physiological arousal was assessed using behavior, questionnaires, subjective report, and skin conductance responses.

Results: A devaluation sensitivity test revealed that both groups could inhibit unnecessary behavioral responses before overtraining. Following overtraining, OCD patients showed greater avoidance habits than control subjects. Groups did not differ in conditioned arousal (skin conductance responses) at any stage. Additionally, groups did not differ in contingency knowledge or explicit ratings of shock expectancy following the habit test. Habit responses were associated with a subjective urge to respond.

Conclusions: These data indicate that OCD patients have a tendency to develop excessive avoidance habits, providing support for a habit account of OCD. Future research is needed to fully characterize the causal role of physiological arousal and explicit fear in habit formation in OCD.

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http://dx.doi.org/10.1016/j.biopsych.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988923PMC
April 2014
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