Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin.

Authors:
Antonio Martinez-Nicolas
Antonio Martinez-Nicolas
University of Murcia
Spain
Juan Antonio Madrid
Juan Antonio Madrid
Chronobiology Laboratory
Pilar Mendiola
Pilar Mendiola
Department of Physiology. Faculty of Biology. University of Murcia. 30100 Murcia
Jorge de Costa
Jorge de Costa
Departamento de Nutrição e Saúde

Exp Gerontol 2013 May 4;48(5):507-16. Epub 2013 Mar 4.

Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.

Adult (48-week-old) and senescent (72-week-old) individually-kept Nothobranchius korthausae were used as experimental subjects to characterise circadian system (CS) function and age-related changes in senescent fish. This species was specifically chosen because it has already shown potential for use as a model system in gerontological studies. The rest-activity rhythm (RAR) in fish can be easily monitored and used to characterise the state of the CS, and it has also been proposed as a reliable model to study sleep-like periods in fish. As they aged, N. korthausae experienced a significant decrease in total daily activity and a progressive impairment of the RAR, accompanied by changes in the regularity, fragmentation and amplitude of the rhythm. The ability of the CS to oscillate autonomously when the two main synchronizers, photoperiod and feeding time, were absent (continuous darkness and random feeding), was also impaired with age, as the capacity to re-synchronise to the light-dark (LD) cycle declined. Melatonin treatment improved the regularity, fragmentation and amplitude of the RAR in senescent fish, and it also improved sleep efficiency. In conclusion, N. korthausae represents a viable model for studying the aging of the circadian system and the restorative effect of chronobiotic substances, such as melatonin.

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http://dx.doi.org/10.1016/j.exger.2013.02.026DOI Listing

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May 2013
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