Exp Gerontol 2013 May 4;48(5):507-16. Epub 2013 Mar 4.
Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
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Exp Gerontol 2011 Dec 28;46(12):970-8. Epub 2011 Aug 28.
Department of Physiology, University of Murcia, Spain.
The life cycle of Nothobranchius korthausae, a Cyprinodontiformes fish, was studied in our laboratory to characterise the ageing process. Some morphological changes, such as spine curvature, skin colour, and fin and eye appearance are described. Growth and survival curves reflected a fast life cycle with rapid initial growth until 4weeks of age, after which the fish grew more slowly before reaching their final size in week 40. Read More
J Neuroendocrinol 2003 Apr;15(4):432-7
Center for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstrasse 27, CH-4025 Basel, Switzerland.
The circadian rhythm of pineal melatonin is the best marker of internal time under low ambient light levels. The endogenous melatonin rhythm exhibits a close association with the endogenous circadian component of the sleep propensity rhythm. This has led to the idea that melatonin is an internal sleep "facilitator" in humans, and therefore useful in the treatment of insomnia and the readjustment of circadian rhythms. Read More
Chronobiol Int 2015 Apr 25;32(3):395-404. Epub 2014 Nov 25.
Faculty of Biology, Department of Physiology, University of Murcia , Murcia , Spain and.
Several studies have been performed to identify age-related changes in the circadian system (CS) but the impairment of the CS and its chronodisruption at the end of an organism life have not been studied in depth. Aging commonly affects the input pathways into the biological clock or restraints their processing, therefore simplifying the system output, the overt rhythms. The purpose of this work was to do a complete characterization of changes that occurs in the CS in the last stage of a vertebrate organism life and to develop tools able to detect in which moment of the last days of life is the animal, using an overt rhythm, the rest-activity rhythm (RAR). Read More
Ann N Y Acad Sci 2005 Dec;1057:327-36
Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina.
The circadian time system involves periodic gene expression at the cellular level, synchronized by a hierarchically superior structure located in the hypothalamic suprachiasmatic nuclei. Treatment of circadian rhythm disorders has led to the development of a new type of agent called "chronobiotics," among which melatonin is the prototype. In elderly insomniacs, melatonin treatment decreased sleep latency and increased sleep efficiency, particularly slow-wave sleep. Read More