Front Neural Circuits 2013 13;7:16. Epub 2013 Feb 13.
Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA ; Department of Mathematical Sciences, Indiana University - Purdue University Indianapolis, IN, USA.
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Respir Physiol Neurobiol 2004 Nov;143(2-3):307-19
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
The generation and shaping of the respiratory motor pattern are performed in the lower brainstem and involve neuronal interactions within the medulla and between the medulla and pons. A computational model of the ponto-medullary respiratory network has been developed by incorporating existing experimental data on the medullary neural circuits and possible interactions between the medulla and pons. The model reproduces a number of experimental findings concerning alterations of the respiratory pattern following various perturbations/stimulations applied to the pons and pulmonary afferents. Read More
Philos Trans R Soc Lond B Biol Sci 2009 Sep;364(1529):2517-26
Department of Neuro- and Sensory Physiology, University Medicine Göttingen, Georg August University, Humboldtallee 23, 37073 Göttingen, Germany.
Control of the timing of the inspiratory/expiratory (IE) phase transition is a hallmark of respiratory pattern formation. In principle, sensory feedback from pulmonary stretch receptors (Breuer-Hering reflex, BHR) is seen as the major controller for the IE phase transition, while pontine-based control of IE phase transition by both the pontine Kölliker-Fuse nucleus (KF) and parabrachial complex is seen as a secondary or backup mechanism. However, previous studies have shown that the BHR can habituate in vivo. Read More
Respir Physiol Neurobiol 2004 Nov;143(2-3):167-75
Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan.
The dorsolateral pons around the parabrachial nucleus is an important participant in respiratory control. This area involves various respiration-related neurons, and their respiratory modulation is thought to arise from afferents from medullary respiratory neurons. Today, however, only a limited number of afferent sources have been identified. Read More
J Neurophysiol 2008 Oct 23;100(4):1770-99. Epub 2008 Jul 23.
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
A large body of data suggests that the pontine respiratory group (PRG) is involved in respiratory phase-switching and the reconfiguration of the brain stem respiratory network. However, connectivity between the PRG and ventral respiratory column (VRC) in computational models has been largely ad hoc. We developed a network model with PRG-VRC connectivity inferred from coordinated in vivo experiments. Read More