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CNS Oncol 2022 May 16:CNS87. Epub 2022 May 16.

Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 259 E Erie St, Chicago, IL 60611, USA.

To ascertain the maximum tolerated dose (MTD)/maximum feasible dose (MFD) of WP1066 and p-STAT3 target engagement within recurrent glioblastoma (GBM) patients. In a first-in-human open-label, single-center, single-arm 3 + 3 design Phase I clinical trial, eight patients were treated with WP1066 until disease progression or unacceptable toxicities. In the absence of significant toxicity, the MFD was identified to be 8 mg/kg. Read More

Front Cell Infect Microbiol 2022 27;12:861677. Epub 2022 Apr 27.

Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA, United States.

The commensal microbes of the gut microbiota make important contributions to host defense against gastrointestinal pathogens, including , the etiologic agent of cholera. As interindividual microbiota variation drives individual differences in infection susceptibility, we examined both host and gene expression during infection of suckling mice transplanted with different model human commensal communities, including an infection-susceptible configuration representing communities damaged by recurrent diarrhea and malnutrition in cholera endemic areas and a representative infection-resistant microbiota characteristic of healthy individuals. In comparison to colonization of animals with resistant microbiota, animals bearing susceptible microbiota challenged with downregulate genes associated with generation of reactive oxygen/nitrogen stress, while in these animals upregulates biofilm-associated genes. Read More

Front Microbiol 2022 28;13:865925. Epub 2022 Apr 28.

State Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, China.

Because of the increased incidence and prevalence, ulcerative colitis (UC) has become a global health issue in the world. Current therapies for UC are not totally effective which result in persistent and recurrent symptom of many patients. with anti-inflammatory effects might be beneficial to the prevention or treatment for UC. Read More

BMJ Case Rep 2022 May 13;15(5). Epub 2022 May 13.

Pediatric Gastroenterology, Indraprastha Apollo Hospital, New Delhi, India.

Protein-losing enteropathy entails an excessive loss of proteins in intestinal tract due to underlying primary or secondary pathologies. It is suspected in patients with chronic diarrhoea and peripheral oedema. Faecal alpha 1 antitrypsin clearance is the gold standard for diagnosis. Read More

JAMA Oncol 2022 May 12. Epub 2022 May 12.

Medical Oncology Department, Centre Léon Bérard, Lyon, France.

Importance: Endometrial cancer is often hormone-dependent and treated with aromatase inhibitors. The PI3K-AKT-mTOR pathway deregulation observed in endometrial cancer drives hormonal resistance, thus supporting the rationale of combining mTOR inhibitor with endocrine therapy.

Objective: To evaluate the safety and efficacy of vistusertib in combination with anastrozole in the treatment of women with hormone receptor-positive recurrent or metastatic endometrial cancer. Read More