Perturbation of cell cycle regulation triggers plant immune response via activation of disease resistance genes.

Proc Natl Acad Sci U S A 2013 Feb 23;110(6):2407-12. Epub 2013 Jan 23.

Department of Plant Biology, Cornell University, Ithaca, NY 14853, USA.

The Arabidopsis gene OSD1 (Omission of the Second Division) and its homolog UVI4 (UV-B-Insensitive 4) are negative regulators of anaphase-promoting complex/cyclosome (APC/C), a multisubunit ubiquitin E3 ligase that regulates the progression of cell cycles. Here we report the isolation of an activation tagging allele of OSD1 as an enhancer of a mutant of BON1 (BONZAI1), a negative regulator of plant immunity. Overexpression of OSD1 and UVI4 each leads to enhanced immunity to a bacterial pathogen, which is associated with increased expression of disease resistance (R) genes similar to the animal NOD1 receptor-like immune receptor genes. In addition, the reduction of function of one subunit of the APC complex APC10 exhibited a similar phenotype to that of overexpression of OSD1 or UVI4, indicating that altered APC function induces immune responses. Enhanced immune response induced by OSD1 overexpression is dependent on CYCB1;1, which is a degradation target of APC/C. It is also associated with up-regulation of R genes and is dependent on the R gene SNC1 (Suppressor of npr1-1, constitutive 1). Taken together, our findings reveal an unexpected link between cell cycle progression and plant immunity, suggesting that cell cycle misregulation could have an impact on expression of genes, including R genes, in plant immunity.

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1217024110
Publisher Site
http://dx.doi.org/10.1073/pnas.1217024110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568333PMC
February 2013
5 Reads

Publication Analysis

Top Keywords

cell cycle
12
plant immunity
12
overexpression osd1
8
osd1 uvi4
8
immune response
8
disease resistance
8
resistance genes
8
genes
6
osd1
5
reduction function
4
function subunit
4
addition reduction
4
immune receptor
4
receptor genes
4
genes addition
4
subunit apc
4
complex apc10
4
indicating altered
4
altered apc
4
apc function
4

References

(Supplied by CrossRef)

Inze et al.
Annual review of genetics 2006

Peters et al.
Nature reviews. Molecular cell biology 2006

Marrocco et al.
Current opinion in plant biology 2010

PNAS 2008

PNAS 2009

Plant Physiology 2009

2010

Development 2009

Saze et al.
The EMBO Journal 2007

d'Erfurth et al.
PLoS biology 2009

d'Erfurth et al.
2010

Similar Publications