[Multiple endocrine neoplasia type 1].

Authors:
Pasi I Salmela

Duodecim 2012 ;128(22):2345-54

OYS, medisiininen tulosalue, sis├Ątautien ja keuhkosairauksien vastuualue.

Multiple endocrine neoplasia type 1 (MEN1) is a complex multisystem disease characterized by the combined occurrence of endocrine tumours of the parathyroid glands, anterior pituitary gland and adrenal glands and the neuroendocrine tumours (NET) of duodenum, pancreas, thymus and bronchus. Malignancy occurs commonly (up to 30 %) and malignant NETs are important causes of the MEN1-related morbidity and mortality. Regular clinical, biochemical and radiologic screening for the syndrome-related tumours are the basis of the life-long surveillance. Early detection and adequate management of these tumours reduce risk of death and morbidity.

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February 2013
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