Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.

Biomarkers 2013 Mar 22;18(2):144-50. Epub 2013 Jan 22.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

The extent of metabolism of [D10]phenanthrene to [D(10)]r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetradeuterophenanthrene ([D10]PheT) could be a biomarker of human metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, leading to identification of smokers particularly susceptible to lung cancer. The longitudinal stability of [D10]PheT was evaluated in 24 cigaret smokers given 7-8 oral doses of [D10]phenanthrene (10 µg) over 5.5 months. [D10]PheT in 6 h urine was quantified after each dose. The overall coefficient of variation for 24 subjects was (mean ± S.D.) 27.4% ± 8.83%. Thus, a single administration of [D10]phenanthrene is likely sufficient to determine a smoker's ability to metabolize it to [D10]PheT.

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http://dx.doi.org/10.3109/1354750X.2012.753553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577059PMC
March 2013
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