Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Endoscopic findings in patients with Schatzki rings: evidence for an association with eosinophilic esophagitis.

Authors:
Michaela Müller Alexander J Eckardt Annette Fisseler-Eckhoff Susanne Haas Ines Gockel Till Wehrmann

World J Gastroenterol 2012 Dec;18(47):6960-6

Department of Gastroenterology, German Diagnostic Clinic, D-65191 Wiesbaden, Germany.

Aim: To investigate endoscopic findings in patients with Schatzki rings (SRs) with a focus on evidence for eosinophilic esophagitis (EoE).

Methods: We consecutively approached all adult patients scheduled for elective outpatient upper endoscopy for a variety of indications at the German Diagnostic Clinic, Wiesbaden, Germany between July 2007 and July 2010. All patients with endoscopically diagnosed SRs, defined as thin, symmetrical, mucosal structures located at the esophagogastric junction, were prospectively registered. Additional endoscopic findings, clinical information and histopathological findings with a focus on esophageal eosinophilia (≥ 20 eosinophils/high power field) were recorded. The criteria for active EoE were defined as: (1) eosinophilic tissue infiltration ≥ 20 eosinophils/hpf; (2) symptoms of esophageal dysfunction; and (3) exclusion of other causes of esophageal eosinophilia. Gastroesophageal reflux disease was excluded by proton pump inhibitor treatment prior to endoscopy. The presence of ≥ 20 eosinophils/hpf in esophageal biopsies in patients that did not fulfil the criteria of EoE was defined as esophageal hypereosinophilia.

Results: A SR was diagnosed in 171 (3.3%; 128 males, 43 females, mean age 66 ± 12.9 years) of the 5163 patients that underwent upper gastrointestinal-endoscopy. Twenty of the 116 patients (17%) from whom esophageal biopsies were obtained showed histological hypereosinophilia (≥ 20 eosinophils/hpf). Nine of these patients (8 males, 1 female, mean age 49 ± 10 years) did not fulfill all diagnostic criteria of EoE, whereas in 11 (9%) patients with ≥ 20 eosinophils/hpf, a definite diagnosis of EoE was made. Three of the 11 patients (27%) with definite EoE had no suspicious endoscopic features of EoE. In contrast, in the 25 patients in whom EoE was suspected by endoscopic features, EoE was only confirmed in 7 (28%) patients. Patients with EoE were younger (mean age 41.5 ± 6.5 vs 50.5 ± 11.5 years, P = 0.012), were more likely to have a history of allergies (73% vs 29%, P = 0.007) and complained more often of dysphagia (91% vs 34%, P = 0.004) and food impaction (36% vs 6%, P = 0.007) than patients without EoE. Endoscopically, additional webs were found significantly more often in patients with EoE than in patients without EoE (36% vs 11%, P = 0.04). Furthermore, the SR had a tendency to be narrower in patients with EoE than in those without EoE (36% vs 18%, P = 0.22). The percentage of males (73% vs 72%, P = 1.0) and frequency of heartburn (27% vs 27%, P = 1.0) were not significantly different in both groups. The 9 patients with esophageal hypereosinophilia that did not fulfil the diagnostic criteria of EoE were younger (mean age 49 ± 10 years vs 58 ± 6 years, P = 0.0008) and were more likely to have a history of allergies (78% vs 24%, P = 0.003) than patients with < 20 eosinophils/hpf. Predictors of EoE were younger age, presence of dysphagia or food impaction and a history of allergies.

Conclusion: A significant proportion of patients with SRs also have EoE, which may not always be suspected according to other endoscopic features.

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v18.i47.6960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531680PMC
December 2012

Publication Analysis

Top Keywords

patients eoe
24
patients
20
eoe
17
≥ eosinophils/hpf
16
endoscopic findings
12
endoscopic features
12
eoe younger
12
younger age
12
criteria eoe
12
findings patients
8
diagnostic criteria
8
eoe 36%
8
esophageal eosinophilia
8
food impaction
8
age years
8
eoe patients
8
eosinophilic esophagitis
8
eoe suspected
8
eoe defined
8
esophageal biopsies
8

Keyword Occurance

Similar Publications

Occurrence and Clinical Impact of Eosinophilic Esophagitis in a Large Cohort of Children With Inflammatory Bowel Disease.

Authors:
Marina Aloi Giulia D'Arcangelo Danilo Rossetti Simone Bucherini Enrico Felici Claudio Romano Massimo Martinelli Valeria Dipasquale Paolo Lionetti Salvatore Oliva

Inflamm Bowel Dis 2022 Aug 9. Epub 2022 Aug 9.

Sapienza University of Rome - Umberto I Hospital, Rome, Italy.

Background: Scarce data have investigated the association between pediatric inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE). We, therefore, aimed to describe the epidemiology and the possible peculiar phenotype and natural history of such an association.

Methods: Case-control study is based on the Italian Society for Pediatric Gastroenterology (SIGENP) national registry. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Tolerance to sterilised cow's milk in patients with eosinophilic oesophagitis triggered by milk.

Authors:
Jesús González-Cervera Ángel Arias Pilar Navarro Rocío Juárez-Tosina María Cobo-Palacios José M Olalla Teresa Angueira-Lapeña Alfredo J Lucendo

Aliment Pharmacol Ther 2022 Aug 2. Epub 2022 Aug 2.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.

Background: Cow's milk protein is the main food trigger for eosinophilic oesophagitis (EoE) in children and adults and should be continuously avoided once identified as such.

Aim: To evaluate tolerance of sterilised cow's milk (boiled instead of UHT processing) with regard to maintenance of EoE remission, health-related quality of life (HRQoL), nutritional intake and allergic sensitisation in patients of all ages with milk-triggered EoE METHODS: We prospectively recruited patients in whom cow's milk was demonstrated to trigger EoE after an empirical food elimination diet-based study. They were given 200 ml of sterilised cow's milk twice daily for 8 weeks. Read More

View Article and Full-Text PDF
August 2022
Similar Publications

Clinical Features of Eosinophilic Esophagitis: A Single Center Experience in Ecuador.

Authors:
Fabián Vásconez Muñoz Pamela Hernández Almeida Estefanía Carrión-Jaramillo Andrea Vásconez Montalvo

Pediatr Gastroenterol Hepatol Nutr 2022 Jul 6;25(4):293-299. Epub 2022 Jul 6.

Department of Pediatrics, Hospital Metropolitano, Universidad Internacional del Ecuador, Quito, Ecuador.

Purpose: Data on eosinophilic esophagitis (EoE) in South America is scarce. Moreover, no studies are available in Ecuador. We evaluated the clinical, endoscopic, and histological characteristics of Ecuadorian children with EoE. Read More

View Article and Full-Text PDF
July 2022
Similar Publications

Epidemiology of Eosinophilic Esophagitis in Patients with Cystic Fibrosis: A Population-Based 5-Year Study.

Authors:
Omar Alaber Ramy Sabe Virginia Baez-Socorro Senthilkumar Sankararaman Erica Roesch Thomas J Sferra

Pediatr Gastroenterol Hepatol Nutr 2022 Jul 6;25(4):283-292. Epub 2022 Jul 6.

Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Purpose: The prevalence of eosinophilic esophagitis (EoE) has been on the rise since it was first described in the 1990s. Several diseases and exogenous factors have been associated with EoE. Our aim was to investigate the epidemiology of EoE in cystic fibrosis (CF) patients. Read More

View Article and Full-Text PDF
July 2022
Similar Publications

Linked color imaging improves the diagnostic accuracy of eosinophilic esophagitis.

Authors:
Yasuhiko Abe Yu Sasaki Makoto Yagi Naoko Mizumoto Yusuke Onozato Takashi Kon Masakuni Shoji Kazuhiro Sakuta Takayuki Sakai Matsuki Umehara Minami Ito Shuhei Nakamura Hidemoto Tsuchida Yoshiyuki Ueno

DEN open 2023 Apr 25;3(1):e146. Epub 2022 Jul 25.

Department of Gastroenterology Faculty of Medicine Yamagata University Yamagata Japan.

Objectives: To assess the usefulness of linked color imaging (LCI), a recently developed image-enhanced endoscopy technique, in the endoscopic diagnosis of eosinophilic esophagitis (EoE).

Methods: Thirty white light images (WLIs) and 30 WLI+LCI images collected from patients with and without EoE were randomly and blindly reviewed by 10 endoscopists, including four experts (Exs) and six non-Exs. Edema, ring, exudate furrows, and strictures were rated on the adjusted EoE endoscopic reference score; the diagnosis of EoE was assessed. Read More

View Article and Full-Text PDF
April 2023
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap