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Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.

Authors:
Agata Sakowicz Wojciech Fendler Malgorzata Lelonek Bartosz Sakowicz Tadeusz Pietrucha

Biochem Genet 2013 Apr 30;51(3-4):230-42. Epub 2012 Dec 30.

Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, 90-725, Lodz, Poland.

This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR-RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.

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http://dx.doi.org/10.1007/s10528-012-9558-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599159PMC
April 2013

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