Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    Brainstem respiratory networks: building blocks and microcircuits.

    Trends Neurosci 2013 Mar 17;36(3):152-62. Epub 2012 Dec 17.
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.
    Breathing movements in mammals are driven by rhythmic neural activity generated within spatially and functionally organized brainstem neural circuits comprising the respiratory central pattern generator (CPG). This rhythmic activity provides homeostatic regulation of gases in blood and tissues and integrates breathing with other motor acts. We review new insights into the spatial-functional organization of key neural microcircuits of this CPG from recent multidisciplinary experimental and computational studies. The emerging view is that the microcircuit organization within the CPG allows the generation of multiple rhythmic breathing patterns and adaptive switching between them, depending on physiological or pathophysiological conditions. These insights open the possibility for site- and mechanism-specific interventions to treat various disorders of the neural control of breathing.
    PDF Download - Full Text Link
    ( Please be advised that this article is hosted on an external website not affiliated with
    Source Status ListingPossible

    Similar Publications

    Respiratory rhythms generated in the lamprey rhombencephalon.
    Neuroscience 2007 Aug 6;148(1):279-93. Epub 2007 Jul 6.
    Centre de Recherche en Sciences Neurologiques, Université de Montréal, Casier Postal 6128, Succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7.
    Brainstem networks generating the respiratory rhythm in lampreys are still not fully characterized. In this study, we described the patterns of respiratory activities and we identified the general location of underlying neural networks. In a semi-intact preparation including the brain and gills, rhythmic discharges were recorded bilaterally with surface electrodes placed over the vagal motoneurons. Read More
    Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms.
    J Neurophysiol 2007 Dec 3;98(6):3370-87. Epub 2007 Oct 3.
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA.
    Mammalian central pattern generators (CPGs) producing rhythmic movements exhibit extremely robust and flexible behavior. Network architectures that enable these features are not well understood. Here we studied organization of the brain stem respiratory CPG. Read More
    Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation.
    J Physiol 2009 Jul 2;587(Pt 14):3539-59. Epub 2009 Jun 2.
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
    We studied respiratory neural activity generated during expiration. Motoneuronal activity was recorded simultaneously from abdominal (AbN), phrenic (PN), hypoglossal (HN) and central vagus nerves from neonatal and juvenile rats in situ. During eupnoeic activity, low-amplitude post-inspiratory (post-I) discharge was only present in AbN motor outflow. Read More