'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care.

Hum Genomics 2012 Aug 2;6:11. Epub 2012 Aug 2.

Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, Wales CF14 4XN, UK.

This report is of a round-table discussion held in Cardiff in September 2009 for Cesagen, a research centre within the Genomics Network of the UK's Economic and Social Research Council. The meeting was arranged to explore ideas as to the likely future course of human genomics. The achievements of genomics research were reviewed, and the likely constraints on the pace of future progress were explored. New knowledge is transforming biology and our understanding of evolution and human disease. The difficulties we face now concern the interpretation rather than the generation of new sequence data. Our understanding of gene-environment interaction is held back by our current primitive tools for measuring environmental factors, and in addition, there may be fundamental constraints on what can be known about these complex interactions.

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http://dx.doi.org/10.1186/1479-7364-6-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500243PMC
August 2012
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References

(Supplied by CrossRef)

J Ernst et al.
Nature 2011

PS Tarpey et al.
Nat Genet 2009

SB Ng et al.
Nature 2009

DN Cooper et al.
Hum Mutat 2010

DG MacArthur et al.
Hum Mol Genet 2010

FL Raymond et al.
Hum Mol Genet 2009

ML Freedman et al.
Nat Genet 2011

LC Schulz et al.
Proc Natl Acad of Sci USA 2010

HD Morgan et al.
Nat Genet 1999

P Gluckman et al.
2005

TA Down et al.
Nat Biotechnol 2008

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