Non-micro-short RNAs: the new kids on the block.

Mol Biol Cell 2012 Dec;23(24):4664-7

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

The advent of ultra-high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16-40 nucleotides in size. We will highlight how some of these non-micro-short RNAs were discovered, as well as their biogenesis, potential mechanisms of action, and role in diverse biological processes, development, and disease. Finally, we will describe what must be done to further our understanding of these enigmatic molecules.

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E12-10-0716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521675PMC
December 2012
8 Reads

Publication Analysis

Top Keywords

non-micro-short rnas
12
nucleotides size
4
16-40 nucleotides
4
range 16-40
4
size will
4
will highlight
4
rnas discovered
4
highlight non-micro-short
4
classes range
4
functional classes
4
decade perspective
4
established decade
4
perspective focus
4
focus non-micro-short
4
comprise variety
4
rnas comprise
4
discovered well
4
biogenesis potential
4
finally will
4
disease finally
4

Similar Publications