Obstet Gynecol 2013 Jan;121(1):14-24
University of British Columbia and BC Cancer Agency, Vancouver, British Columbia, Canada.
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Ann Intern Med 2006 Mar;144(6):397-406
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Joseph L. Mailman School of Public Health, Columbia University, and New York Presbyterian Hospital, New York, New York 10032, USA.
Background: For BRCA1 or BRCA2 mutation carriers, decision analysis indicates that prophylactic surgery or chemoprevention leads to better survival than surveillance alone.
Objective: To evaluate the cost-effectiveness of the preventive strategies that are available to unaffected women carrying a single BRCA1 or BRCA2 mutation with high cancer penetrance.
Design: Markov modeling with Monte Carlo simulations and probabilistic sensitivity analyses. Read More
Arch Gynecol Obstet 2014 Jun 4;289(6):1325-30. Epub 2014 Jan 4.
1st Department of Obstetrics and Gynecology, Campus Innenstadt, Ludwig-Maximilians-University Munich, Maistrasse 11, 80337, Munich, Germany.
Introduction: Breast reconstruction with salpingo-oophorectomy can easily be performed in patients with genetic mutations increasing the risk for mammary and ovarian carcinoma. However, many patients are skeptical about having several surgeries, as they may result in additional anesthesiological risks as well as multiple visible scars. Therefore, the purpose of this study was to evaluate the feasibility of prophylactic mastectomy and breast reconstruction combined with simultaneous transmammary salpingo-oophorectomy for BRCA carriers. Read More
N Engl J Med 2002 May 20;346(21):1609-15. Epub 2002 May 20.
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.
Background: Risk-reducing salpingo-oophorectomy is often considered by carriers of BRCA mutations who have completed childbearing. However, there are limited data supporting the efficacy of this approach. We prospectively compared the effect of risk-reducing salpingo-oophorectomy with that of surveillance for ovarian cancer on the incidence of subsequent breast cancer and BRCA-related gynecologic cancers in women with BRCA mutations. Read More
BJOG 2011 Jun 10;118(7):814-24. Epub 2011 Mar 10.
Department of Gynaecological Oncology, EGA Institute for Women's Health, UCL, London, UK.
Objective: To compare surgical outcomes and occult cancer rates at risk-reducing salpingo-oophorectomy in BRCA carriers and high-risk women who had not undergone genetic testing.
Design: Prospective cohort study.
Setting: Tertiary high-risk familial gynaecological cancer clinic. Read More