Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse.

Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Jan;115(1):95-103

Department of Pathology, Stanford University, Stanford, California 94305-5324, USA.

Background: PERP is a p53/p63-regulated gene encoding a desmosomal protein that plays a critical role in cell-cell adhesion and tumor suppression.

Study Design: We evaluated PERP expression in different grades of oral dysplasia (34 cases) and at different stages of invasive squamous cell carcinoma (SCC), and correlated the latter with clinical outcome. A tissue microarray consisting of nondysplastic mucosa, carcinoma in situ, SCC, and nodal metastases from 33 patients with human papilloma virus-negative SCC was stained for PERP and E-cadherin.

Results: Complete loss of PERP expression was associated with worse local control in patients with SCC. The 5-year local control rate was 91% for patients with partial PERP loss versus 31% for those with complete loss (P = .01).

Conclusions: This is the first study to show that loss of PERP expression correlates with the transition to SCC and with increased local relapse in patients with oral cavity SCC.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S22124403120167
Publisher Site
http://dx.doi.org/10.1016/j.oooo.2012.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523282PMC
January 2013
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