The cost effectiveness of treating paediatric cancer in low-income and middle-income countries: a case-study approach using acute lymphocytic leukaemia in Brazil and Burkitt lymphoma in Malawi.

Arch Dis Child 2013 Feb 30;98(2):155-60. Epub 2012 Nov 30.

Children's Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, California 90027, USA.

Approximately 90% of children with cancer reside in low-income and middle-income countries (LMIC) where healthcare resources are scarce and allocation decisions difficult. The cost effectiveness of treating childhood cancers in these settings is unknown. The objective of the present work was to determine cost-effectiveness thresholds for common paediatric cancers using acute lymphoblastic leukaemia (ALL) in Brazil and Burkitt lymphoma (BL) in Malawi as examples. Disability-adjusted life years (DALYs) prevented by treatment were compared to the gross domestic product (GDP) per capita of each country to define cost-effectiveness thresholds using WHO-CHOICE ('CHOosing Interventions that are Cost-Effective') guidelines. The case examples were selected due to the data available and because ALL and BL both have the potential to yield significant health gains at a low cost per patient treated. The key findings were as follows: the 3:1 cost/DALY prevented to GDP/capita ratio for ALL in Brazil was US $771,225; expenditures below this threshold were cost effective. Costs below US $257,075 (1:1 ratio) were considered very cost effective. Analogous thresholds for BL in Malawi were US $42,729 and US $14,243. Actual costs were far less. In Brazil, US $16,700 was spent to treat each patient while in Malawi total drug costs were less than US $50 per child. In summary, treatment of certain paediatric cancers in LMIC is very cost effective. Future research should evaluate actual treatment and infrastructure expenditures to help guide policymakers.

Download full-text PDF

Source
http://adc.bmj.com/cgi/doi/10.1136/archdischild-2011-301419
Publisher Site
http://dx.doi.org/10.1136/archdischild-2011-301419DOI Listing
February 2013
15 Reads
1 Citation
2.900 Impact Factor

Publication Analysis

Top Keywords

cost effective
12
leukaemia brazil
8
paediatric cancers
8
burkitt lymphoma
8
low-income middle-income
8
cost effectiveness
8
lymphoma malawi
8
effectiveness treating
8
middle-income countries
8
brazil burkitt
8
cost-effectiveness thresholds
8
cost
6
data potential
4
selected data
4
gains low
4
potential yield
4
yield health
4
health gains
4
patient treated
4
prevented gdp/capita
4

Similar Publications