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Atherosclerosis 2021 Feb 16;321:39-44. Epub 2021 Feb 16.

AOU Maggiore della Carità, Eastern Piedmont University, Novara, Italy. Electronic address:

Background And Aims: The impact of advanced age on the optimal duration of dual antiplatelet therapy (DAPT) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary revascularization (PCI) is still greatly debated. Therefore, the aim of the present sub-analysis of the REDUCE trial was to assess the impact of age on the comparison between a short 3 months vs standard 12 months DAPT in ACS patients treated with the COMBO Dual Stent Therapy.

Methods: The REDUCE trial is a prospective, multicenter, investigator-initiated study that randomized ACS patients undergoing PCI with the COMBO drug eluting stent to either 3 or 12 months of DAPT. Read More

Cardiovasc Pathol 2021 Feb 24:107328. Epub 2021 Feb 24.

Department of Basic Medical Sciences, Histology and Embryology, Faculty of Dentistry, Marmara University, Istanbul, Turkey.

Introduction: . Diabetes Mellitus (DM) has been known to be a risk factor for the development of more severe form of saphenous vein graft disease after coronary artery bypass grafting (CABG). We aimed to evaluate the impact of type II-DM on histopathological features of great saphenous vein grafts of patients undergoing CABG PATIENTS AND METHODS: . Read More

Crit Rev Eukaryot Gene Expr 2021 ;31(1):79-92

Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.

Diabetic cardiomyopathy is characterized as abnormal function and structure of myocardium associated with diabetes irrespective of other cardiac risk factors like hypertension or coronary artery disease (CAD). The pathogenesis of DCM was not well understood in the past due to its complexity but it has been discovered recently. Various factors are found to be associated with the onset of DCM including impaired calcium handling, remodeling of extracellular matrix (ECM), increased oxidative stress, altered metabolism, mitochondrial dysfunction, and endothelial dysfunction. Read More

Cardiovasc Interv Ther 2021 Feb 27. Epub 2021 Feb 27.

Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.

Previous studies suggested possible discordant quantitative measurements between different IVUS catheters and/or systems. The purpose of this study was to assess compatibility of two different IVUS catheters and consoles for quantitative measurements of coronary arteries. (1). Read More

Microcirculation 2021 Feb 26:e12689. Epub 2021 Feb 26.

Department of Life Sciences, The Centre for Inflammation Research and Translational Medicine (CIRTM), Brunel University London, Uxbridge, Middlesex, UB8 3PH, UK.

The intertwined processes of thrombosis and inflammation (termed 'thrombo-inflammation') are significant drivers of cerebrovascular diseases and as such they represent prime targets for drug discovery programs focusing on treatment and management of cerebrovascular diseases. Most cerebrovascular events result from chronic systemic microcirculatory dysfunction due to underlying conditions e.g. Read More