Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

Authors:
Qing Lan Chao A Hsiung Keitaro Matsuo Yun-Chul Hong Adeline Seow Zhaoming Wang H Dean Hosgood Kexin Chen Jiu-Cun Wang Nilanjan Chatterjee Wei Hu Maria Pik Wong Wei Zheng Neil Caporaso Jae Yong Park Chien-Jen Chen Yeul Hong Kim Young Tae Kim Maria Teresa Landi Hongbing Shen Charles Lawrence Laurie Burdett Meredith Yeager Jeffrey Yuenger Kevin B Jacobs I-Shou Chang Tetsuya Mitsudomi Hee Nam Kim Gee-Chen Chang Bryan A Bassig Margaret Tucker Fusheng Wei Zhihua Yin Chen Wu She-Juan An Biyun Qian Victor Ho Fun Lee Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Jin Hee Kim Yu-Tang Gao Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Amy Hutchinson Wen-Chang Wang Robert Klein Charles C Chung In-Jae Oh Kuan-Yu Chen Sonja I Berndt Xingzhou He Wei Wu Jiang Chang Xu-Chao Zhang Ming-Shyan Huang Hong Zheng Junwen Wang Xueying Zhao Yuqing Li Jin Eun Choi Wu-Chou Su Kyong Hwa Park Sook Whan Sung Xiao-Ou Shu Yuh-Min Chen Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen William Pao Young-Chul Kim Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Jian Su Chih-Liang Wang Haixin Li Alan Dart Loon Sihoe Zhenhong Zhao Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Takashi Kohno Sun-Seog Kweon Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Wong-Ho Chow Bu-Tian Ji John K C Chan Minjie Chu Yao-Jen Li Jun Yokota Jihua Li Hongyan Chen Yong-Bing Xiang Chong-Jen Yu Hideo Kunitoh Guoping Wu Li Jin Yen-Li Lo Kouya Shiraishi Ying-Hsiang Chen Hsien-Chih Lin Tangchun Wu Yi-Long Wu Pan-Chyr Yang Baosen Zhou Min-Ho Shin Joseph F Fraumeni Dongxin Lin Stephen J Chanock Nathaniel Rothman

Nat Genet 2012 Dec 11;44(12):1330-5. Epub 2012 Nov 11.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10(-18)), 6q22.2 (rs9387478, P = 4.14 × 10(-10)) and 6p21.32 (rs2395185, P = 9.51 × 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.

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http://dx.doi.org/10.1038/ng.2456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169232PMC
December 2012
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