Sensory neuromodulators in functional nausea and vomiting: predictors of response.

Authors:
Amit Patel
Amit Patel
University of Chicago Medical Center
Chicago | United States
Gregory S Sayuk
Gregory S Sayuk
Washington University School of Medicine
United States
Vladimir M Kushnir
Vladimir M Kushnir
Washington University School of Medicine
United States

Postgrad Med J 2013 Mar 30;89(1049):131-6. Epub 2012 Oct 30.

Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.

Background: Tricyclic antidepressants (TCAs) are known to benefit subjects with functional nausea and vomiting (FNV), but it is not known if alternate neuromodulators are also beneficial. We retrospectively evaluated outcomes and clinical predictors of response in FNV subjects treated with any neuromodulator, including TCAs.

Methods: We identified 94 subjects (43.8±1.4 year, 79 F) with FNV (Rome III criteria) over a 12 year period, treated with neuromodulators and followed up for 8.5±1.1 months. Clinical presentation, demographics and gastric emptying study (GES) findings (when available) were extracted. Likert scales determined symptom severity at baseline and symptom response or remission at follow-up. Outcomes and predictors of response were evaluated using univariate and multivariate analyses.

Results: At least moderate symptom improvement was reported by 72.3%, and 22.3% had symptom remission. Proportions achieving moderate improvement and remission, and mean outcome Likert scores were similar regardless of neuromodulator agent used or GES status. On univariate and multivariate logistic regression analysis, baseline symptom severity affected symptom response, and pain negatively impacted symptom remission to treatment (p≤0.04 for each); GES status failed to predict treatment response or remission.

Conclusions: Symptom improvement with neuromodulators may be seen in over two-thirds of subjects with FNV regardless of the specific agent administered. Response may be suboptimal in pain predominant presentations.

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Source
http://dx.doi.org/10.1136/postgradmedj-2012-131284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957227PMC
March 2013
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