Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.

Cancer Causes Control 2013 Jan 31;24(1):13-25. Epub 2012 Oct 31.

Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan).

Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer.

Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52).

Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.

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http://dx.doi.org/10.1007/s10552-012-0078-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529822PMC
January 2013
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References

(Supplied by CrossRef)
Article in CA Cancer J Clin
R Siegel et al.
CA Cancer J Clin 2012
Article in CA Cancer J Clin
DM Parkin et al.
CA Cancer J Clin 2005
Article in Nat Rev Gastroenterol Hepatol
S Raimondi et al.
Nat Rev Gastroenterol Hepatol 2009
Article in Am J Epidemiol
SM Lynch et al.
Am J Epidemiol 2009
Article in Int J Cancer
EJ Jacobs et al.
Int J Cancer 2010
Article in Nat Genet
L Amundadottir et al.
Nat Genet 2009
Article in Cancer Res
BM Wolpin et al.
Cancer Res 2010
Article in Cancer Epidemiol Biomarkers Prev
BM Wolpin et al.
Cancer Epidemiol Biomarkers Prev 2010
Article in Arch Intern Med
AA Arslan et al.
Arch Intern Med 2010
Article in Int J Cancer
A Vrieling et al.
Int J Cancer 2010
Article in Diabetes Care
RA DeFronzo et al.
Diabetes Care 1991

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