Prevalence of hepatopathy in type 1 diabetic children.

BMC Pediatr 2012 Oct 6;12:160. Epub 2012 Oct 6.

Division of Pediatric Gastroenterology, Hepatology & Nutrition, University of King Saud bin Abdulaziz for Health sciences Children's Hospital, PO box 59046, King Fahad Medical City, Riyadh, 11525, Kingdom of Saudi Arabia.

Background: The Prevalence of liver disease among diabetics has been estimated to be between 17% and 100%. Most of these data were obtained from adult studies. The aim of our study was to screen for liver disease among type 1 diabetic children.

Methods: Children with type 1 diabetes following in clinic have been examined for existence of liver disease, from November 2008 to November 2009. All were subjected to the following: History, physical examination, liver function tests, fasting lipid profile, HbA1C, and ultrasound of the liver. A hyperechogenic liver and/or hepatomegaly on ultrasound were attributed most likely to excess glycogen or fat in the liver, after negative extensive work-up to rule out other underlying liver disease.

Results: 106 children with type 1 diabetes were studied: age ranged between 8 months to 15.5 years, sixty two patients were females. Twenty two patients (21%) were identified to have abnormal findings on ultrasound of the liver: 10 patients had hepatomegaly and 12 had hyperechogenic liver. The group with hyperechogenic liver had poorer glycemic control than patients with normal liver (Mean HbA1c 12.14% Vs 10.7%; P value = 0.09). Hyperechogenic liver resolved in 60% at 6 months follow-up upon achieving better glycemic control.

Conclusions: Hyperechogenic liver and/or hepatomegaly are not uncommon in children with type 1 diabetes and tend to be more prevalent among children with poor glycemic control. Type 1 diabetes related hepatopathy is reversible by optimizing glycemic control. Because of its safety, and reliability, ultrasound can be used to screen for hepatopathy in type 1 diabetic child.

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2431-12-160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506494PMC
October 2012
Get 20% Off Journals at LWW.com

Similar Publications

[Prevalence of diabetes, antidiabetic treatment and chronic diabetic complications reported by general practitioners].

Przegl Lek 2005 ;62(4):201-5

NZOZ Przychodnia Medycyny Rodzinnej w Szczecinie.

Introduction: Prevalence of type 2 diabetes has increased greatly over the past decade and focus of care for people with diabetes has shifted from specialists to general practitioners (GPs). Because of lack of the central registry, a real number of diagnosed diabetes in Poland is unknown, as unknown is the prevalence of diabetes in patients attending primary health care, provided treatment and a prevalence of chronic diabetic complications registered by GPs.

Aim Of Study: Assessment of the prevalence of diabetes registered in primary health care, recommended antidiabetic treatment and prevalence of microangiopathic diabetic complications diagnosed by GPs. Read More

View Article and Full-Text PDF
December 2005

Prevalence of hepatic abnormalities in a cohort of Egyptian children with type 1 diabetes mellitus.

Pediatr Diabetes 2010 Nov;11(7):462-70

Pediatrics Department, Cairo University, Cairo, Egypt.

Background And Aim: Children with type 1 diabetes mellitus (T1DM) are frequently investigated for hepatic abnormalities. This study was carried out to report on the prevalence of hepatic abnormalities in diabetic children and adolescents and to highlight the possible etiology and appropriate management.

Methods: The study included 692 children (333 were males) with T1DM attending the Diabetes Unit at Cairo University Pediatric Hospital. Read More

View Article and Full-Text PDF
November 2010

Survey on acute and chronic complications in children and adolescents with type 1 diabetes at Muhimbili National Hospital in Dar es Salaam, Tanzania.

Diabetes Care 2007 Sep 11;30(9):2187-92. Epub 2007 Jun 11.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Objective: The purpose of this study was to assess glycemic control and complications of type 1 diabetes in children and adolescents in Tanzania.

Research Design And Methods: This demographic and clinical survey included 99 children aged between 5 and 18 years attending Muhimbili National Hospital Clinic for Diabetes. A structured questionnaire was used for evaluating socioeconomic data and for estimation of the prevalence of acute complications occurring over the last 6 months. Read More

View Article and Full-Text PDF
September 2007

Thailand diabetes registry project: type of diabetes, glycemic control and prevalence of microvascular complications in children and adolescents with diabetes.

J Med Assoc Thai 2006 Aug;89 Suppl 1:S10-6

Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objective: To determine the etiology, glycemic control and prevalence of microvascular complications in Thai diabetic patients who were diagnosed at the age of less than 18 years and who attended diabetes clinics in university or tertiary care hospitals.

Material And Method: A cross-sectional, multi-center, hospital-based diabetes registry was carried out from diabetes clinics of 11 tertiary centers. Demographic data including laboratory results and microvascular complications were recorded. Read More

View Article and Full-Text PDF
August 2006