Familial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variants.

Authors:
Elham Kharazmi
Elham Kharazmi
German Cancer Research Center
Germany
Eero Pukkala
Eero Pukkala
Helsinki University Central Hospital
Finland
Kristina Sundquist
Kristina Sundquist
Lund University
Sweden
Hauke Thomsen, Dr.
Hauke Thomsen, Dr.
GeneWerk GmbH
Senior Bioinformatician
Bioinformatics, Biostatistics, Genetics
Heidelberg, Baden-Württemberg/Germany | Germany
Kari Hemminki
Kari Hemminki
German Cancer Research Center (DKFZ)
Heidelberg | Germany

Br J Haematol 2012 Dec 1;159(5):585-8. Epub 2012 Oct 1.

Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.

Despite recent successes in the identification of genetic susceptibility loci, no familial risk has been demonstrated for childhood acute lymphoblastic leukaemia (ALL). We identified 3994 childhood ALL cases from two cancer registries; family members were obtained from population registers. The standardized incidence ratio for familial risk in singleton siblings and twins was 3·2 (95% confidence interval 1·5-5·9) and 162·6 (70·2-320·4), respectively. The present data constitute the first demonstration of familial risk for singleton siblings; the high risk for twins is believed to result from shared prenatal blood circulation. The data suggest that currently unidentified genetic loci underlie these observed familial effects.

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http://dx.doi.org/10.1111/bjh.12069DOI Listing

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December 2012
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