The role of circadian clocks in metabolic disease.

Authors:
Dr. Min-Dian Li, PhD
Dr. Min-Dian Li, PhD
Harvard TH Chan School of Public Health
Postdoctoral Fellow
Cellular and Molecular Physiology
Boston, MA | United States
Zhong Wang
Zhong Wang
Beijing Institute of Nanoenergy and Nanosystems
China

Yale J Biol Med 2012 Sep 25;85(3):387-401. Epub 2012 Sep 25.

Department of Cellular and Molecular Physiology, Section of Comparative Medicine, and Integrative Cell Signaling and Neurobiology of Metabolism Program, Yale School of Medicine, New Haven, CT 06520, USA.

The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with perturbed energy metabolism. In this article, we will review current knowledge about molecular mechanisms of the circadian clock and the role of clocks in the physiology and pathophysiology of metabolic tissues.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447202PMC

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September 2012
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