Pathology 2012 Oct;44(6):571-4
J Integr Neurosci 2021 Mar;20(1):153-155
Department of Neurology, Harrison International Peace Hospital, Hengshui, 053000 Hebei, P. R. China.
This paper reports a case of Trousseau syndrome with intracranial venous sinus thrombosis as the first manifestation, which is relatively rare in the clinic. A 44-year-old female patient presented with a blurred vision of the visual substance for 2 months, and the condition was aggravated with a headache for 10 days. The final diagnosis was intracranial venous sinus thrombosis and acute myeloid leukemia subtype M2. Read More
Ann Hematol 2021 Apr 6. Epub 2021 Apr 6.
Department of Hematology, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Chronic neutrophilic leukemia (CNL) is a rare but serious myeloid malignancy. In a review of reported cases for WHO-defined CNL, CSF3R mutation is found in about 90% cases and confirmed as the molecular basis of CNL. Concurrent mutations are observed in CSF3R-mutated CNL patients, including ASXL1, SETBP1, SRSF2, JAK2, CALR, TET2, NRAS, U2AF1, and CBL. Read More
Cureus 2021 Feb 17;13(2):e13387. Epub 2021 Feb 17.
Ophthalmology, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.
Leukemia is a systematic cancer of the blood and blood-forming tissues that affects multiple organs. Acute myeloid leukemia (AML) is the most common type of leukemia that affects adults. Ophthalmic manifestations of leukemia could be observed in both acute and chronic leukemias. Read More
J Immunother Cancer 2021 Mar;9(3)
School of Medicine, University of Leeds, Leeds, UK
Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50% of intratumoral cells, making them highly appropriate therapeutic delivery vehicles. Because myeloid cells are ubiquitously present in the body, we recently established a lentiviral vector containing matrix metalloproteinase 14 (MMP14) promoter, which is active specifically in tumor-infiltrating myeloid cells as opposed to myeloid cells in other tissues, and resulted in a specific delivery of transgenes to brain metastases in HSC gene therapy. Read More
Mol Med Rep 2021 Apr 26;23(4). Epub 2021 Jan 26.
Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Toll‑like receptor (TLR) 2/4 serves an important regulatory role in nerve tissue injury. However, the downstream and potential mechanisms remain to be elucidated. The present study was designed to investigate the roles of the TLR2/4‑major myeloid differentiation response gene 88 (MyD88)‑NF‑κB signaling pathway in the development of intracranial aneurysm. Read More