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J Allergy Clin Immunol 2021 Mar 1. Epub 2021 Mar 1.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Centre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo, Norway. Electronic address:

Background: Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied five Finnish and two Omani patients with loss of DIAPH1 presenting with SCBMS, mitochondrial dysfunction and immunodeficiency.

Objective: To further characterize phenotypes and disease mechanisms associated with loss of DIAPH1. Read More

Stem Cells 2021 Mar 4. Epub 2021 Mar 4.

Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, P. R. China.

Group 2 innate lymphoid cells (ILC2s) are recognized as key controllers and effectors of type 2 inflammation. Mesenchymal stem cells (MSCs) have been demonstrated to alleviate type 2 inflammation by modulating T lymphocyte subsets and decreasing T 2 cytokine levels. However, the effects of MSCs on ILC2s have not been investigated. Read More

Eur J Haematol 2021 Mar 4. Epub 2021 Mar 4.

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15701, Athens, Greece.

Objective: 3´ tRNA-derived fragments (3´ tRFs) are important epigenetic regulators in normal and pathological conditions. In this study, we aimed to explore the potential value of a 3´ tRF as a prognostic and/or screening biomarker for B-cell chronic lymphocytic leukemia (B-CLL).

Methods: Publicly available next-generation sequencing data from 20 B-CLL cases were analyzed, followed by prediction of targets of the most abundantly and ubiquitously expressed 3´ tRFs, leading to selection of tRF-Leu . Read More

Cent Eur J Immunol 2020 30;45(4):403-408. Epub 2021 Jan 30.

Department of Gynecology, Jiangxi Maternity and Child Healthcare Hospital, Nanchang City, Jiangxi, PR China.

Introduction: There has a close relationship between the balance of T helper 17 (Th17) cells and Foxp3+ regulatory T cells (Treg) and unexplained recurrent pregnancy loss (URPL). The present study is to investigate the regulatory effect of daphnetin, which is extracted from Daphne odora Var, on the balance of Th17 and Treg cells in the peripheral blood mononuclear cells (PBMCs) from patients with URPL.

Material And Methods: PBMCs were isolated from 35 pregnant women with URPL and 35 women with normal early pregnancies, respectively and treated with daphnetin for three days. Read More

Int J Neurosci 2021 Mar 3:1-10. Epub 2021 Mar 3.

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

In the present study we aimed to investigate the effects of nano-curcumin supplementation on gene expression and serum levels of IL-4 and TGF-β in migraine patients. Forty participants with episodic migraine were randomly allocated to receive 80 mg nano-curcumin ( = 20) or placebo ( = 20) in a randomized double-blind clinical trial for two months. At the beginning and the end of the study, the interictal serum levels and gene expression of IL-4 and TGF-β in peripheral blood mononuclear cells (PBMCs) isolated from migraine patients were measured, using ELISA and real-time PCR methods, respectively. Read More